S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway
Top from left: Acosta Gonzalez Herik Rodrigo, Noriko Suganuma, Ni Luh Gede Yoni Komalasari, Yuma Gohara, Nahoko Tomonobu, Miyoko Kubo, Ken-ichi Yamamoto, Fan Jiang and Naoko Mizuta; Bottom from left: Rie Kinoshita, Masakiyo Sakaguchi, Jin Zhou, Cuiming Sun and Hitoshi Murata; Absent: Atsuko Yamakawa
The S100 proteins are low-molecular-weight proteins and have a Ca2+ binding EF-hand motif in their structure. The S100 family proteins are involved in cancer growth and metastasis, and S100A11 is highly expressed in various types of cancers and plays a crucial role in cancer progression when secreted into extracellular fluid. However, most of S100A11 is still present within cancer cells. This study aimed to elucidate the intracellular functions of S100A11 within cancer cells, primarily focusing on colorectal cancer cells. We identified novel binding partners in the inner membrane, many of which are desmosome proteins. S100A11 regulates the expression level of DSG1, a component protein of desmosome, by which S100A11 activates the TCF pathway via promoting nuclear translocation of g-catenin from the desmosome. The identified new pathway greatly helps to comprehend S100A11’s nature in colorectal cancers and others.
Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In Vitro Cellular & Developmental Biology-Animal, 60:1138-1149, 2024.
